Predictors of transient congenital primary hypothyroidism: data from the German registry for congenital hypothyroidism (AQUAPE “HypoDok”)

Abstract Neonatal screening for congenital primary hypothyroidism (CH) may not distinguish between transient (TCH) and permanent dysfunction (PCH), causing potential overtreatment concerns in affected families. To specify the indication interruption of therapy, we analysed German registry “HypoDok” infants with CH, which oversees 1625 patients from 49 participating centres Germany Austria 1997 until today. A total 357 a thyroid gland loco typico were identified retrospectively grouped according to cessation (TCH, n = 24) or continuation (PCH, 333) l -thyroxine ( -T 4 ) treatment at 2 years age. The receiver operating characteristic (ROC) analysis was performed identify cutoffs predicting TCH by TSH concentrations dosages. Gestational ages, birth weights prevalence associated malformations comparable both groups. cutoff concentration 73 mU/L. daily dosage 1 year 3.1 μg/kg (90% sensitivity, 63% specificity; 36 μg/day) age 2.95 (91% 59% 40 μg/day). At age, specificity (71%) increased when these parameters considered together. Conclusion : decision continue cease CH diagnosed neonatal be based on their individual dosages Thus, PCH distinguished; avoided; families reassured. What is Known: • course transient, overtreatment. dose predict hypothyroidism. New: represent reliable predictors higher sensitivity together order select eligible who qualify withdrawal.